Objective To explore and analyze the predictive value of serum macrophage inflammatory protein-3α(MIP-3α)and chemokine C-C-motif receptor 3(CCR3)for postoperative recurrence and metastasis of colon cancer patients.Methods A total of 198 colon cancer patients admitted to our hospital from June 2018 to May 2021 were included as the colon cancer group.According to the follow-up results,they were grouped into a recurrence and metastasis group(n=65)and a non-recurrence and metastasis group(n=133).192 healthy volunteers who underwent physical examinations in our hospital during the same period were included as the control group.The expression levels of serum MIP-3αand CCR3 were detected,and the general clinical data of the patients were analyzed.Multivariate logistic regression was applied to analyze the influencing factors of postoperative recurrence and metastasis in colon cancer patients.Receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of serum MIP-3αand CCR3 for postoperative recurrence and metas-tasis in colon cancer patients.Results Compared with the control group,the serum levels of MIP-3α and CCR3 in the co-lon cancer group were obviously increased(t/P=22.813/＜0.001;15.164/＜0.001).The serum levels of MIP-3αand CCR3 in the recurrence and metastasis group were obviously higher than those in the non-recurrence and metastasis group(t/P=11.813/＜0.001;12.545/＜0.001).The differences in TNM staging,differentiation degree,and preoperative CEA levels between the recurrent and non-recurrent metastatic groups were statistically obvious(x2/P=4.694/0.030;14.253/＜0.001;5.602/0.018).TNM staging T3+T4,degree of low differentiation,and elevation of preoperative CEA,MIP-3α,and CCR3 were all risk fac-tors for postoperative recurrence and metastasis in patients[OR(95％CI)=1.869(1.008-3.465);1.998(1.097-3.640);1.887(1.090-3 267);2.335(1.194-4.565);2.318(1.200-4.478)].ROC curve results showed that the AUC predicted by serum MIP-3α,CCR3,and their combination for postoperative recurrence and metastasis in colon cancer patients was 0.808,0.795,and 0.899,respectively.The AUC predicted by the combination was obviously higher than that predicted by MIP-3α(Z=2.989,P=0.003)and CCR3(Z=2.575,P=0.010)alone.Conclusion The serum levels of MIP-3αand CCR3 are elevated in patients with colon cancer,they have certain auxiliary predictive value for postoperative recurrence and metastasis,and may serve as potential biomarkers.
Colon cancerPostoperative recurrence and metastasisMacrophage inflammatory protein-3αChemo-kine C-C-motif receptor 3
维普
万方数据
