Efficacy of thalidomide combined with FOLFOX6 regimen in the treatment of postoperative liver metastasis from colorectal cancer and its impact on survival rate
Objective To investigate the effect of thalidomide combined with FOLFOX6 on postoperative liver me-tastasis of colorectal cancer,tumor markers and survival rate.Methods A total of 130 patients with postoperative liver me-tastasis of colorectal cancer admitted to the First General Surgery Department of Sichuan Armed Police Corps Hospital from January 2021 to January 2023 were selected as the study objects,and were divided into a single group(65 cases)and a combined group(65 cases)by random number table method.The single group was treated with FOLFOX6 regimen and the combined group was treated with thalidomide combined with FOLFOX6 regimen.The clinical effect was compared between the two groups after treatment.Tumor markers[serum carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)],inflammatory response indicators[interleukin-4(IL-4),tumor necrosis factor-α(TNF-α)and chemokine receptor 4(CXCR4)],physical status and survival of 2 groups before and after treatment;the adverse reactions were recorded and compared be-tween the two groups during treatment.Results The total effective rate of the combined group was higher than that of the single group(5231％vs.33.85％,x2/P=4.517/0.034).After 4 cycles of treatment,CEA and CA199 in 2 groups were lower than before treatment,and CEA and CA199 in combination group were lower than those in single group(t/P=30.898/0.001,17.832/0.001);IL-4,TNF-αand CXCR4 decreased in 2 groups,and the combined group was lower than the single group(t/P=11.080/0.001,12.162/0.001,7.533/0.001);KPS scores increased in both groups,and the combined group was higher than the single group(t/P=4.515/0.001);The 12-month survival rate of the combined group was higher than that of the single group(50.77％vs.30.77％,x2=5.383,P=0.020);there was no significant difference in the incidence of adverse reactions be-tween the two groups(P＞0.05).Conclusion The treatment of postoperative liver metastases of colorectal cancer can ef-fectively prolong the survival time and reduce the inflammatory response,the effect is ideal,and the clinical application value is high.
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