Objective To explore the diagnostic value of color Doppler ultrasound(CDU)combined with serum cysteine-rich 61(Cyr61)and angiopoietin like protein 3(ANGPTL3)in patients with chronic heart failure(CHF).Methods Eighty-six cases of CHF patients admitted to the Department of Cardiology of the Northwest University Affiliated Hospital Xi'an No.3 Hospital,from December 2020 to December 2023 were selected as the study group,and the patients were divided into 58 cases of subgroups of class Ⅱ-Ⅲ and 28 cases of subgroup of class Ⅳ according to the cardiac function grading of the New York Heart Association(NYHA).Another 86 cases were selected as healthy control group from the same period of hospital health checkups.Enzyme-linked immunosorbent assay(ELISA)was used to determine serum Cyr61 and ANGPTL3 levels;Pearson correlation analysis was used to analyze the correlation between serum Cyr61 and ANGPTL3 lev-els and cardiac function indexes;multifactorial logistic regression was used to analyze the influencing factors of CHF pa-tients;and subjects'work characteristics(ROC)curves were used to evaluate the CDU and serum Cyr61,ANGPTL3 levels for the diagnostic value of CHF.Results Serum Cyr61,ANGPTL3 levels and left ventricular end-diastolic internal diameter(LVEDD)and left atrial diameter(LAD)were significantly higher and left ventricular ejection fraction(LVEF)was significantly lower in the study group than in the healthy control group(t/P=9.779/＜0.001,35.751/＜0.001,18.376/＜0.001,21.451/＜0.001,49.742/＜0.001);serum Cyr61 and ANGPTL3 levels and LVEDD and LAD were significantly higher in the class Ⅳ sub-group of CHF patients than in the class Ⅱ-Ⅲ subgroup,and LVEF was significantly lower than in the class Ⅱ-Ⅲ sub-group(t/P=11226/＜0.001,37.440/＜0.001,7.786/＜0.001,27.001/＜0.001,13 303/＜0.001);serum Cyr61 and ANGPTL3 levels were positively correlated with LVEDD and LAD and negatively correlated with LVEF(r/P=0501/＜0.001,0510/＜0.001,-0.522/＜0.001,0.515/＜0.001,0.517/＜0.001,-0.532/＜0.001);multifactorial logistic regression analysis showed that high Cyr61,high ANGPTL3,high LVEDD,and high LAD were independent risk factors for patients with CHF[OR(95％CI)=3.108(1590-6.076),4378(2.011-9533),3.420(1.452-8.054),2.058(1.429-2.963)],and high LVEF was an independent protective factor[OR(95％CI)=0.521(0.329-0.824)];the AUCs for the diagnosis of CHF for LVEDD,LAD,LVEF,Cyr61,ANGPTL3 and the combination of the five were:0.764,0.832,0.815,0.810,0.808,and 0.976,and the area under the curve(AUC)of the com-bination of the five was greater than the AUC of LVEDD,LAD,LVEF,Cyr61,and ANGPTL3 diagnosed alone(Z/P=2.527/0.031,2.675/0.024,2.689/0.020,2.679/0.018,2.680/0.023).Conclusion Serum Cyr61 and ANGPTL3 are greatly elevated in CHF patients,and CDU combined with serum Cyr61 and ANGPTL3 can improve the diagnostic value for CHF patients.
Chronic heart failureColor Doppler ultrasoundCysteine-rich 61Angiopoietin like protein 3Diagnos-tic value
维普
万方数据
