Objective To explore the value of high-resolution magnetic resonance imaging(high-resolution MR)combined with serum micrornA-140-3p(miR-140-3p)and micromA-223-3p(miR-223-3p)in the assessment of the vulnerabili-ty of carotid atherosclerotic plaques.Methods A total of 86 patients with carotid atherosclerosis admitted to the Depart-ment of Neurology of the First People's Hospital of Lianyungang City from January 2022 to December 2023 were selected as the study objects.According to the pathologically confirmed plaque status,the patients were divided into a plaque vulnera-ble group(42 cases)and a non-plaque vulnerable group(44 cases).The serum levels of miR-140-3p and miR-223-3p were detected by real-time fluorescence quantitative PCR(qRT-PCR).Kappa test was used to analyze the consistency of high-resolution MR Detection and gold standard in diagnosing vulnerable carotid atherosclerotic plaques.Multivariate Logistic regression was used to analyze the influencing factors of plaque vulnerability in patients with carotid atherosclerosis.Re-ceiver operating characteristic(ROC)curve analysis of the diagnostic value of high-resolution MR,miR-140-3p and miR-223-3p in plaque vulnerability in patients with carotid atherosclerosis.Results The serum miR-140-3p level in the plaque vulner-able group was lower than that in the non-plaque vulnerable group,and the serum miR-223-3p level was higher than that in the non-plaque vulnerable group(t/P=6.033/＜0.001,6.367/＜0.001).There was no significant difference in arterial remode-ling type and plaque distribution between the two groups(P＞0.05).Kappa test showed that the high resolution MR Test was generally consistent with the gold standard in the diagnosis of vulnerable carotid atherosclerotic plaque(Kappa value=0.603).Multivariate Logistic regression analysis showed that high CRP and miR-223-3p were independent risk factors for vul-nerable plaque in patients with carotid atherosclerosis[OR(95％CI)=1.685(1.051-2.702),3.054(2.008-4.645)].The high level of miR-140-3p was an independent protective factor[OR(95％CI)=0.752(0.616-0.918)].The area under the curve(AUC)of plaque vulnerability in patients with carotid atherosclerosis diagnosed by high-resolution MR,miR-140-3p,miR-223-3p and their combination were 0.800,0.860,0.884 and 0.981,respectively.The AUC of the combination of the three was greater than that diagnosed by high-resolution MR,miR-140-3p and miR-223-3p alone(Z/P=4.537/＜0.001,2.980/0.003,2.869/0.004).Conclusion High-resolution MR Combined with serum miR-140-3p and miR-223-3p detection can improve the diagnostic value of carotid atherosclerotic plaque vulnerability.
Carotid atherosclerosisPlaque vulnerabilityHigh-resolution magnetic resonance imagingMicroribo-nucleic acid-140-3pMicroribonucleic acid-223-3p
维普
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