Objective This study aims to investigate the diagnostic value of combined detection of serum tumor necrosis factor receptor associated protein 1(TRAP1)and cysteine protease inhibitor SN(Cystatin-SN)in benign and malig-nant pulmonary nodules,providing reference for clinical related diagnosis.Methods One hundred and ninety-eight patients with pulmonary nodules who visited between July 2021 and June 2023 were selected as the study subjects.According to pathological examination results,they were divided into a benign nodule group of 42 cases and a malignant nodule group of 156 cases.Compare the serum levels of TRAP1 and Cystatin-SN between the benign nodule group and the malignant nod-ule group;Compare the results of single and combined serum TRAP1 and Cystatin-SN tests;Compare the diagnostic effica-cy of single or combined examinations for malignant pulmonary nodules;And observe the pathological characteristics of malignant pulmonary nodules,further analyze the correlation between serum TRAP1,Cystatin-SN levels and pathological features,and the results of multiple factor Poisson regression.Results The serum levels of TRAP1 and Cystatin-SN in the malignant nodule group were significantly higher than those in the benign nodule group,with statistical significance(t/P=32 273/＜0.001、30.512/＜0.001).In the group of malignant pulmonary nodules,there was a statistically significant difference in the levels of serum TRAP1 and Cystatin-SN in lymph node metastasis and histological differentiation(t/P=11.812/＜0.001、5.547/＜0.001,16.837/＜0.001、8.923/＜0.001);In the group of malignant pulmonary nodules,there was no statistically significant difference in the levels of serum TRAP1 and Cystatin-SN in terms of gender,clinical symptoms,nodule location,and pathological type(P＞0.05).ROC curve analysis results showed that the area under the curve(AUC)of serum TRAPI and Cystatin-SN alone and the combination of them were 0.831,0.863,0.938,respectively,and the AUC of the combination was significantly higher than that predicted by TRAPI and Cystatin-SN alone,with statistical significance(Z=2.127、2.038,P＜0.05)Conclusion Serum TRAPI and Cystatin-SN have good clinical value in the differential diagnosis of benign and malignant pulmonary nodules,and it has been found that serum TRAPI and Cystatin-SN levels are highly expressed in pa-tients with malignant pulmonary nodules,which may become potential serum biomarkers.
Pulmonary nodulesSerum tumor necrosis factor receptor associated protein 1Cysteine protease in-hibitor SNDiagnostic value
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