Objective To investigate the expression of peroxiredoxin 4(PRDX4)and alpha-1,3-mannosyltransferase(ALG3)in breast cancer and their relationship with clinicopathological features and prognosis.Methods The cancerous tis-sue,paracancerous tissue and related data of 126 patients with breast cancer diagnosed and treated in General Surgery De-partment of Renhe Hospital Affiliated to Three Gorges University during June 2020 to June 2022 were retrospectively collect-ed.Immunohistochemistry was used to measure the expression of PRDX4 and ALG3 proteins in tissues.According to the protein expression,patients were separated into negative expression group and positive expression group.Multivariate Cox regression analysis was applied to screen for factors affecting 2-year prognosis.Results The proportions ofPRDX4 posi-tive expression and ALG3 positive expression in cancer tissues were higher than those in adjacent tissues(x2/P=68.980/＜0.001,72.278/＜0.001).The proportions of T2-T4,N1-N2,poorly differentiated tissues,and lymph node metastasis in the PRDX4 positive expression group and ALG3 positive expression group were higher than those in the PRDX4 negative ex-pression group and ALG3 negative expression group(x2/P=8.749/0.003,14.655/＜0.001,15.935/＜0.001,15.154/＜0.001;7.653/0.006,9559/0.002,17.594/＜0.001,9.433/0.002).The 2-year survival rate of patients with positive expression of PRDX4(52/85,61.18％)was lower than that of patients with negative expression of PRDX4(35/41,85.37％)in breast cancer(x2=7.572,P=0.006).The 2-year survival rate of patients with positive expression of ALG3(54/89,60.67％)was lower than that of patients with negative expression of ALGB(33/37,89.19％)in breast cancer(x2=9.943,P=0.002).The proportion of T2-T4 and N1-N2 stages in the death group was higher than that in the survival group(x2/P=8.188/0.004,8.022/0.005).PRDX4 positive expression and ALG3 positive expression were independent risk factors for death of breast cancer patients within 2 years[HR(95％CI)=2.759(1.462～5207),2.805(1.469～5.356)].Conclusion The positive expression rates of PRDX4 and ALG3 in breast cancer tissues are higher than those in adjacent tissues.The high expression of both is related to T stage,N stage,tissue differentiation degree,lymph node metastasis,and prognosis.
Breast cancerPeroxiredoxin 4Alpha-1,3-mannosyltransferasePrognosis
维普
万方数据
