lncRNA相关基因在三阴性乳腺癌中的作用研究进展

Research progress on the role of IncRNA-related genes in triple-negative breast cancer

喻茂文 ¹喻珊珊 ²廖振宇¹

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作者信息

1. 610400 成都,四川大学华西医院金堂医院实验医学科
2. London,Britain,Queen Mary University of London,Barts Cancer Institue
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摘要

三阴性乳腺癌(TNBC)是乳腺癌的一种特殊类型,具有较高的复发率、侵袭率.近年研究发现,长链非编码RNA(lncRNA)在TNBC中异常表达,可通过多基因或多信号转导途径参与TNBC细胞增殖分化、迁移、自噬及凋亡等生物学进程,对TNBC发生发展具有重要作用.lncRNA调控的分子作用机制是当前TNBC研究热点,可用于辅助诊断、预测预后,有望成为TNBC潜在作用靶点.文章从lncRNA的特征、在TNBC中具体作用机制及预测预后价值等方面作一综述.

Abstract

Triple negative breast cancer(TNBC)is a special type of breast cancer,which has a high recurrence rate and invasion rate.Recent studies have found that abnormal expression of long non-coding RNA(lncRNA)in TNBC can participate in biological processes such as proliferation,differentiation,migration,autophagy and apoptosis of TNBC cells through multi-gene or multi-signal transduction pathways,and play an important role in the occurrence and development of TNBC.The molecular mechanism of action regulated by lncRNA is currently a hot topic in TNBC research,which can be used to assist diagnosis and prognosis prediction,and is expected to become a potential target of TNBC.This article re-views the characteristics of lncRNA,its specific mechanism of action in TNBC and its prognosis.

关键词

三阴性乳腺癌/长链非编码RNA/增殖/迁移/凋亡/作用机制

Key words

Triple negative breast cancer/Long non-coding RNA/Proliferation/Migration/Apoptosis/Mechanism

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出版年

2024

疑难病杂志

中国医师协会

疑难病杂志

CSTPCD

影响因子：1.171

ISSN：1671-6450

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