Triple negative breast cancer(TNBC)is a special type of breast cancer,which has a high recurrence rate and invasion rate.Recent studies have found that abnormal expression of long non-coding RNA(lncRNA)in TNBC can participate in biological processes such as proliferation,differentiation,migration,autophagy and apoptosis of TNBC cells through multi-gene or multi-signal transduction pathways,and play an important role in the occurrence and development of TNBC.The molecular mechanism of action regulated by lncRNA is currently a hot topic in TNBC research,which can be used to assist diagnosis and prognosis prediction,and is expected to become a potential target of TNBC.This article re-views the characteristics of lncRNA,its specific mechanism of action in TNBC and its prognosis.
Triple negative breast cancerLong non-coding RNAProliferationMigrationApoptosisMechanism
喻茂文、喻珊珊、廖振宇
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610400 成都,四川大学华西医院金堂医院实验医学科
London,Britain,Queen Mary University of London,Barts Cancer Institue
维普
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