Objective To investigate the correlation of serum neuromodulin 1(NRG1)and acyl-coenzyme A syn-thetase long chain family member 1(ACSL1)with the degree of coronary stenosis and prognosis in patients with acute myo-cardial infarction(AMI).Methods From January 2021 to June 2023,203 patients with AMI admitted to the Department of E-mergency Medicine of the Second Affiliated Hospital of Army Medical University were selected as AMI group and 105 healthy volunteers were selected as healthy control group.According to Gensini score,AMI patients were divided into mild coronary stenosis subgroup(63 cases),moderate coronary stenosis subgroup(81 cases)and severe coronary stenosis sub-group(59 cases).According to 1-year prognosis,they were divided into poor prognosis subgroup(52 cases)and good prognosis subgroup(151 cases).Serum NRG1 and ACSL1 levels were detected by enzyme-linked immunosorbent assay.Ser-um NRG1 and ACSL1 levels were detected by enzyme-linked immunosorbent assay.Spearman correlation analysis was used to analyze the correlation between Gensini score and serum NRG1 and ACSL1 levels in AMI patients.The relationship be-tween serum NRG1 and ACSL1 levels and the prognosis of AMI patients was determined by multivariate unconditional lo-gistic regression.Receiver operating characteristic curve was used to analyze the predictive efficiency of serum NRG1 and ACSL1 levels.Results Compared with the control group,the serum levels of NRG1 and ACSL1 in the AMI group were in-creased(t/P=15.801/＜0.001,15.824/＜0.001).The levels of serum NRG1 and ACSL1 in mild coronary stenosis subgroup,moderate coronary stenosis subgroup and severe coronary stenosis subgroup increased in turn(F/P=277.241/＜0.001,423.452/＜0.001).Gensini score was positively correlated with serum NRG1 and ACSL1 levels in AMI patients(rs/P=0.764/＜0.001,0.772/＜0.001).The incidence of poor prognosis in 203 patients with AMI was 25.62％(52/203)after 1 year of fol-low-up.Compared with the good prognosis subgroup,the serum levels of NRG1 and ACSL1 in the poor prognosis sub-group were increased(t/P=7.040/＜0.001,7.865/＜0.001).The independent risk factors for poor prognosis in patients with AMI were high Gensini score,high ACSL1 and high NRG1[OR(95％CI)=1.041(1.019-1.062),1272(1.120-1.443),1.337(1.193-1.497)].The area under the curve of serum NRG1 and ACSL1 levels combined to predict the poor prognosis of AMI pa-tients was 0.899,which was greater than 0.783 and 0.786 predicted by serum NRG1 and ACSL1 levels alone(Z/P=3.730/＜0.001,3.329/＜0.001).Conclusion The levels of serum NRG1 and ACSL1 in AMI patients are increased,which is related to the aggravation of coronary stenosis and poor prognosis.The combination of serum NRG1 and ACSL1 levels is more effec-tive in predicting the prognosis of AMI patients.
Acute myocardial infarctionNeuregulin-1Acyl-coenzyme A synthetase long chain family member 1Coronary artery stenosis degreePrognosis
万方数据
维普
