Objective To observe the therapeutic effect of Huahong Granules combined with nifuratelomycin vagi-nal soft gel in patients with recurrent mycotic vaginitis(VVC).Methods From April 2022 to August 2023,124 patients with relapsed VVC in our hospital were selected and divided by random lot method.62 patients in the control group were given nifuratrol vaginal soft capsule treatment,and 62 patients in the experimental group were combined with Huahong granules based on the control group.The efficacy,TCM syndrome score,recurrence rate,vaginal microecology,inflammation level and adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 88.71％,which was higher than the 74.19％of the control group(x2/P=4.324/0.038).After treatment,the scores of itch-ing in the genitals,excessive leucorrhea,and thick or beancurd-like discharge in the experimental group were lower than those in the control group,respectively(t/P=6.954/＜0.001,5.906/＜0.001,3.627/＜0.001).After treatment,the colony densi-ty and flora diversity in the experimental group were better than those in the control group,and the vaginal pH value was lower than that in the control group(t/U/P=4.919/＜0.001,3.041/0.002,2.978/0.003).After treatment,the levels of high-sensi-tivity C-reactive protein(hs-CRP)and granulocyte colony-stimulating factor(GM-CSF)in the experimental group were lower than those in the control group,respectively,while the level of transforming growth factor β(TGF-β1)was higher than that in the control group(t/P=3.182/0.002,2.934/0.004,3 287/0.001).After 6 months of follow-up,the recurrence rate of the experi-mental group was 30.65％,which was lower than the 4839％of the control group(x2/P=4.083/0.043).There was no signifi-cant difference in the incidence of adverse reactions between the experimental group and the control group(P＞0.05).Con-clusion In the treatment of recurrent WC,Huahong Granules and nifuratel vaginal soft gel have significant effects,which can reduce recurrence,relieve clinical symptoms,improve vaginal microecology,reduce inflammation level,and have high safety.
关键词
外阴阴道假丝酵母菌病/花红颗粒/硝呋太尔制霉素/复发/阴道微生态
Key words
Vulvovaginal candidiasis/Huahong Granules/Nifuratel to mycin/Recurrence/Vaginal microecology
维普
万方数据