Observation on the effect of subclinical dose of esketamine hydrochloride in cesarean section
Objective To explore the efficacy and safety of subclinical doses of esketamine hydrochloride used in combined spinal-epidural anesthesia for cesarean section.Methods From December 2021 to December 2022,78 pregnant women who received ropivacaine combined spinal-epidural anesthesia for cesarean section in our hospital were randomly divided into observation group and control group.The fetuses in the observation group were intravenously injected with 0.2 mg/kg esketamine hydrochloride after delivery,while the fetuses in the control group were intravenously injected with an equal amount of normal saline.Compared the inter-group differences in anesthesia indicators,anesthesia effect,visual analogue scale(VAS)score,sedation score(Ramsay)and incidence of adverse reactions at different time points.Results There was no difference in anesthesia indicators between the two groups(all P＞0.05);the excellent and good rate of anesthesia in the observation group was higher than that in the control group(97.44％VS 82.05％,P＜0.05);The VAS scores of the observation group at 3h,6h,and 9h after surgery were lower than that in control group(mean VS mean,P＜0.05)and Ramsay score were higher than that in the control group(mean VS mean,P＜0.05);There was no statistical difference in the incidence of adverse reactions between the two groups(10.26％VS 15.38％,P＞0.05).Conclusions Ropivacaine combined spinal-epidural anesthesia during cesarean section,the intravenous injection of subclinical doses of esketamine hydrochloride is efficient and safe,and can enhance the sedative and analgesic effect during and after surgery,which is worthy of further research and promotion.
万方数据
维普
