Study on the correlation of therapeutic effect and safety of different dosage forms of rifampicin in blood concentration
Objective To prospectively observe the correlation of blood concentration,therapeutic effect and adverse reactions in the therapeutic process of different dosage forms of rifampicin.Methods Active TB patients hospitalized in Kunming Third People's Hospital from July 2022 to December 2022 were randomly divided into oral rifampicin group(59 cases)and injection rifampicin group(64 cases).The difference blood concentration of rifampicin between the two groups was observed for seven days.At the same time,rifampicin was divided into＜8mg/L,8-24mg/L and＞24mg/L according to blood concentration,and the correlation of different blood concentrations of rifampicin,the therapeutic effect and the occurrence of adverse drug reactions was observed.Results The blood concentration of rifampicin in injection group was significantly higher than that in oral group,the difference was statistically significant(P＜0.05).When the blood concentration of rifampicin was＞24mg/L,the number of lesions absorbed in the injection group was 25 cases(52.1％)more than that in the oral group(14 cases,25.0％).12 cases(21.4％)occurred liver damage in the injection group and 4 cases(17.4％)more than that in the oral group,with statistical significance(P＜0.05).Conclusions The higher the blood concentration of rifampicin,the better the lesion absorption effect is.However,the incidence of liver damage is also higher.Therefore,the monitoring of blood concentration of rifampicin should be strengthened.
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万方数据
维普
