Analysis on the literature of adverse reactions caused by Lorlatinib
Objective:To analyze the occurrence and clinical features of adverse drug reactions(ADRs)of Lorlatinib,so as to provide reference for clinical safe medication.Methods Through searching Pubmed,CNKI and VIP databases,the case report of ADR caused by Lorlatinib were collected and analyzed statistically.Results A total of 13 literatures on ADR caused by Lorlatinib were searched,A total of 44 ADRs occurred in 15 patients,including 7 males and 8 females,56.82％of ADRs occurred eithin 1d to one month.ADR mainly involved respiratory system,central and peripheral nervous system.Conclusions We should strengthen monitoring for clinical use of Lorlatinib,especially in patients with a history of lung or brain radiotherapy,brain metastases,psychiatric disease and taking related drugs.Pay more attentions to drug interactions and disease effect on drugs,look sharp on the ADR to ensure clinical drug safety.
Lorlatinibadverse drug reactionliterature analysis
NETL
NSTL
万方数据
维普
