A Meta-analysis of the relationship between the severity and laboratory characteristics of COVID-19 patients
Objective To explore the relationship between disease severity and laboratory characteristics of CO VID-19 patients through systematic review.Methods References met the inclusion criteria were retrieved from PubMed,Embase,Cochrane Library,CNKI,Wanfang Data and VIP databases.The quality evaluation was completed by QUADAS-2 tool,data meta-analysis was performed by Review Manager 5.3 software.Results A total of 25 studies were included,involving 3741 research subjects(2520 mild/moderate cases and 1221 severe/critical cases).Compared with mild/moderate patients,leukocytes,neutrophils,alanine aminotransferase,aspartate aminotransfer-ase,total bilirubin,creatinine,C-reactive protein,lactate dehydrogenase,procalcitonin,D-dimer and fibrinogen were significantly increased in severe/critical patients.Lymphocytes,albumin,CD3+T,CD4+T and CD8+T were significantly decreased.There were no significant difference in the change of platelet,hemoglobin and CD4/CD8 ratio.Conclusions Laboratory characteristics of blood routine examination,markers of liver and kidney function,markers of inflammation/infection and coagulation function are closely related to the severity of CO VID-19 patients.
COVID-19degree of severitylaboratory characteristicsMeta-analysis
NETL
NSTL
万方数据
维普
