Retrospective cohort study on risk factors for patients with sepsis combined with septic cardiomyopathy in Emergency Department
Objective To explore whether metabolic,infection,biochemical and other test indicators are related to myocardial injury in patients with sepsis.Methods It collected 497 adult patients(aged≥18 years)diagnosed with sepsis or septic shock in the emergency department of a top three hospital from June 2021 to September 2023,and divide them into sepsis-induced cardiomyopathy group and non-sepsis-induced cardiomyopathy group based on whether they were complicated with sepsis-induced cardiomyopathy(SIC).A retrospective study was used to collect clinical data from all selected patients,compared the differences in indicators between the sepsis-induced cardiomyopathy group and the non-sepsis-induced cardiomyopathy group,calculated the cut-off values by ROC,and then used COX regression(forward stepwise method)to analyze the possible high-risk factors for myocardial injury in sepsis patients.Survival analysis was performed by Kaplan Meier.Results Among the 497 patients,there were 201 cases in the SIC group and 296 cases in the non-SIC group.The mortality rate in the SIC group was 33.81％(68/201),while in the non-SIC group was 13.51％(40/296),indicating a statistically significant difference in survival between the two groups.The levels of BUN,Cr,UA,TT3,TT4,FT3,FT4,PCT,CRP,IL-6,IL-10,and ferritin in the SIC group were higher than those in the non-SIC group;TC,TSH and PLT were all lower than those in the non-SIC group,with statistically significant differences(P＜0.05).CR≥84.5,Bun≥8.35,IL-10≥11.75,uric acid ≥116.50 could be used as a predictor in patients with septic cardiomyopathy,in which the risk ratio of increased BUN complicated with SIC increased(HR=1.86,P=0.049).Conclusions BUN increased is a high-risk factor for sepsis complicated with cardiomyopathy.
万方数据
维普
