Pathogenesis and treatment of minimal change disease
minimal change disease(MCD)is the most common type of primary nephrotic syndrome in children and adolescents.The main clinical manifestations are massive proteinuria,hypoproteinemia,edema and hyperlipidemia.At present,the conventional treatment or glucocorticoid treatment of MCD has a good effect and prognosis,but there is still recurrence and glucocorticoid resistance,creating difficulties for treatment.With the in-depth study of minimal change disease,people have a certain understanding of the occurrence and development mechanism of the disease,and provide relevant basis for drug therapy in clinical practice.This article reviews the research progress of the pathogenesis of MCD and the relationship between miR-499 and minimal change disease.
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