摘要
目的 探索丙型肝炎肝硬化患者QT间期延长的分布特征及影响因素.方法 以115例丙型肝炎肝硬化患者为研究对象,收集人口统计学及入院首次临床资料,根据QTc数值将患者分为延长组和未延长组,通过单因素筛选、二元logistic回归探索QT间期延长的影响因素,并绘制ROC曲线明确其诊断效能.结果 QTc间期延长组患者和未延长组相比,血清K、Na、Hb、ALB、TBIL、PT、RBG、TC 及 MELD、MELD-Na、Child-Pugh 评分差异有统计学意义(P＜0.05),其中 Child-Pugh 评分(OR=1.353,95％CI:1.007～1.82)和 RBG(OR=1.155,95％CI:1.001～1.332)是 QTc 间期延长的独立危险因素(P＜0.05),血清 K(OR=0.204,95％CI:0.058～0.714)和 Hb(OR=0.973,95％CI:0.956～0.991)则为保护因素(P＜0.05);K、Hb、RBG和Child-Pugh评分判断QTc延长的ROC曲线下面积分别为0.648、0.709、0.645和0.695.结论 血清K、Hb、RBG和Child-Pugh评分改变是丙型肝炎肝硬化患者QT间期延长的独立影响因素.
Abstract
Objective To explore the distribution characteristics of QT interval extension in patients with hepatitis C cirrhosis and its influencing factors.Methods A total of 115 patients with hepatitis C cirrhosis were selected as the study objects,and the demographics and initial clinical data were collected.The patients were divided into extension group and no-extension group according to QTc values.The influencing factors of QT interval extension were explored through univariate screening and binary logistic regression,and the ROC curves were drawn to clarify their diagnostic efficacy.Results There were statistically significant differences in serum K,Na,Hb,ALB,TBIL,PT,RBG,TC and MELD,MELD-Na,Child-Pugh scores in patients in the QTc interval extension group and no-extension group(P＜0.05).Child-Pugh score(OR=1.353,95％CI:1.007～1.82)and RBG(OR=1.155,95％CI:1.001～1.332)were the independent risk factors for QTc interval extension(P＜0.05),Whereas the serum K(OR=0.204,95％CI:0.058～0.714)and Hb(OR=0.973,95％CI:0.956～0.991)were protective factors(P＜0.05);The areas under QTc extended ROC curve which judged by K,Hb,RBG,and Child-Pugh scores were 0.648,0.709,0.645 and 0.695,respectively.Conclusions Changes in serum K,Hb,RBG and Child-Pugh scores are independent influencing factors in the QTc interval extension in patients with hepatitis C cirrhosis.
维普
万方数据