Analysis on the change characteristics of laboratory indexes in HCV patients co-infected with HIV and/or HBV
Objective To analyze the changes of laboratory indicators in the body caused by HCV combined with HIV and/or HBV infection.Methods A total of 3492 patients with hepatitis C treated in Kunming Third People's Hospital from Oct.2013 to Oct.2019 were selected as the research objects.They were divided into HBV/HCV co-infection group,HIV/HCV co-infection group,H1V/HCV/HBV co-infection group and single HCV infection group.The laboratory test indexes of four groups of infected patients before antiviral treatment were retrospectively analyzed.Results There were differences in gender and age in the four groups(P＜0.01).The infection age of HIV/HCV group and HIV/HCV/HBV group was lower than that of HCV/HBV group and single HCV group,and the difference was statistically significant(P＜0.01),and the proportion of male patients was higher in all four groups.The proportion of genotype 2 in HIV/HCV group was lower than that in HCV/HBV group and single HCV group,while the proportion of genotype 3 in HIV/HCV group was higher than that in single HCV group.The WBC,NE,Hh and PLT of HIV/HCV group were significantly lower than those of single HCV group,while LYM and RBC of HIV/HCV group and HIV/HCV/HBV group were significantly lower than those of single HCV group and HBV/HCV group.Compared with the single HCV group,the PTA was significantly decreased and INR was significantly prolonged in the HCV/HBV group,and TT was significantly prolonged in the HIV/HCV group compared with the single HCV group.TBIL,DBIL,IBIL,ALT and TBA in HCV/HBV group and HIV/HBV group were significantly higher than those in single HCV group,while ALB and PA were significantly lower.Conclusions Male patients with HCV infection are more common in Yunnan area,with diverse genotypes.Patients with HCV co-infection are more likely to have abnormal blood routine,impaired liver function and coagulopathy.
hepatitis B virushepatitis C virushuman immunodeficiency virusco-infectionlaboratory indexes
万方数据
维普
