摘要
慢性肾脏病患者由于免疫功能低下以及肾功能受损导致感染结核的风险增加,而结核病患者中慢性肾脏病的患病率也明显增高,两病共存为临床的治疗带来了极大的困难.慢性肾脏病患者抗结核药物的选择和剂量调整非常重要,尤其是终末期GFR严重下降的结核患者抗结核药物剂量、频率、用药时间等的选择上需要结合2种疾病特点,考虑患者机体各方面的因素.本文总结了目前结核合并慢性肾脏病患者临床特征、治疗、预防、预后,为临床用药提供参考.
Abstract
Due to low immune function and impaired renal function,chronic kidney disease(CKD)patients have an increased risk of tuberculosis infection,and the prevalence of chronic kidney disease in tuberculosis patients has also increased significantly.The coexistence of the two diseases has brought great difficulties to clinical treatment.The selection and adjustment of the dose of anti-tuberculosis drugs in chronic kidney disease patients are very important,especially for tuberculosis patients with severe decline in GFR in the end stage,the selection of the dose,frequency,and duration of anti-tuberculosis drugs need to combine the characteristics of the two diseases,and consider various factors of the patient's body.This article summarizes the clinical characteristics,treatment,prevention and prognosis of patients with tuberculosis combined with chronic kidney disease,providing reference for clinical medication.
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