首页|两性霉素B胆固醇硫酸酯复合物治疗真菌感染的应用进展

两性霉素B胆固醇硫酸酯复合物治疗真菌感染的应用进展

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真菌感染的病例逐年增加,死亡率居高不下,两性霉素B因其抗真菌谱广、活性强的优点被列为治疗真菌感染最有效的药物之一,但其毒副作用也较为明显,两性霉素B胆固醇硫酸酯复合物是新型制剂的代表药物,本文对其结构特点、治疗不同真菌感染的效果以及副作用等进行综述.
Advances in the application of amphotericin B cholesterol sulfate complex in the treatment of fungal infections
The number of cases of fungal infection is increasing year by year,and the mortality rate remains high.Amphotericin B has been listed as one of the most effective drugs for the treatment of fungal infections due to its wide anti-fungal spectrum and strong activity,but its toxic side effects are also obvious.Amphotericin B cholesterol sulfate complex is a representative drug of new preparations.This paper reviews its structural characteristics,effects and side effects in the treatment of different fungal infections.

fungal infectionamphotericin Bamphotericin B cholesterol sulfate complex

肖琦琦、于闵、罗建蓉、彭江丽、姚晓蝶、陈永刚

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大理大学药学院,云南 大理 671000

昆明市第三人民医院/云南省传染性疾病临床医学中心感染科,云南 昆明 650041

昆明市第三人民医院/云南省传染性疾病临床医学中心临床药学部,云南 昆明 650041

真菌感染 两性霉素B 两性霉素B胆固醇硫酸酯复合物

2024

云南医药
中华医学会云南分会

云南医药

影响因子:0.459
ISSN:1006-4141
年,卷(期):2024.45(6)