Effect of Chaigui Granule on Cytokines in Prostatic Fluid of Type Ⅲ Prostatitis
Objective To observe the clinical efficacy of Chaigui granules in the treatment of type Ⅲ prostatitis with water stasis syndrome and its impact on prostate fluid cytokines and other indicators.Methods Patients diagnosed with water stasis type Ⅲ prostatitis were randomly assigned to either a treatment group consisting of 35 cases or a control group comprising 27 cases.The control group was given sustained-release capsules of tamsulosin hydrochloride orally,while the treatment group was given Chaigui granules orally.Compare the chronic prostatitis symptom Index(NIH-CPSI)score,changes in prostate fluid cytokines,and clinical efficacy between two groups of patients before and after treatment.Results The national institutes of health chronic prostatitis symptom index(NIH-CPSI)scores in the treatment group showed a significant reduction after the treatment when compared to their scores before treatment(P＜0.05).This decrease was also notably greater than the scores in the control group after treatment.Additionally,the levels of interleukins IL-2,IL-6,and IL-8 in the treatment group showed a significant reduction post-treatment compared to their levels before treatment(P＜0.05).The levels of IL-2 and IL-6 were significantly lower in the treatment group than in the control group post-treatment.Furthermore,when comparing the total effectiveness rates of traditional Chinese medicine syndromes between the two groups,the treatment group demonstrated a significantly higher effectiveness rate than the control group(P＜0.05).Conclusion Chaigui granules can significantly improve the clinical symptoms of patients with type Ⅲ prostatitis with water stasis syndrome,and enhance clinical efficacy.Its mechanism may be related to the regulation of cytokine levels in prostate fluid,which is worth further research.
Chaigui granulestype Ⅲ prostatitissyndrome of mutual accumulation of water and blood stasisprostate fluidcell factor
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