摘要
目的 采用数据挖掘技术对吕光荣教授在中医药治疗失眠方面的用药规律进行深入分析.方法 收集吕光荣教授2021年4月1日—2023年2月29日在云南省中医医院门诊诊治的失眠患者的临床资料.将所得资料录入Microsoft Excel中建立处方数据库,应用R4.3.1软件对药物进行频次统计、性味归经统计、关联规则分析.结果 纳入符合标准的方剂336首,涉及175味中药,高频药物为:茯苓、白术、丹参、甘草、酸枣仁,频次最高的药物为茯苓(281次),药性分布:温＞平＞寒＞凉＞热,以温性(43.70％)为主;药味分布:甘＞辛＞苦＞酸,以甘味居多(39.65％);归经主要归脾、肺、肝经,以脾经为主(20.45％);共现次数最高的是酸枣仁-茯苓(223次),最佳聚类数为3类,有3组药物的相关性较高.结论 吕光荣教授治疗失眠,坚持先病后证的学术思想,倡导因人制宜、补清和缓的治则,以恢复机体阴阳和、营卫调、五脏安的状态.
Abstract
Objective To conduct an in-depth analysis of the medication patterns in the treatment of insomnia by Professor Lu Guangrong using traditional Chinese medicine(TCM)through data mining techniques.Methods Clinical data from all insomnia patients treated by Professor Lu Guangrong at the outpatient clinic of Yunnan Province Traditional Chinese Medicine Hospital were collected.The data were entered into a prescription database established in Microsoft Excel,and R software version 4.3.1 was used for frequency statistics of the medications,analysis of properties and meridian tropism,and association rule analysis.Results A total of 336 prescriptions that met the criteria were included,involving 175 Chinese medicinal herbs.The most frequently used herbs were Poria(Fu Ling),Atractylodes(Bai Zhu),Salvia miltiorrhiza(Dan Shen),Licorice(Gan Cao),and Spine Date Seed(Suan Zao Ren),with Poria being the most frequently used(281 times).The distribution of the properties of the herbs was:warm＞neutral＞cold＞cool＞hot,with warm(43.70％)being predominant;the flavor distribution was:sweet＞pungent＞bitter＞sour,with sweet flavors being most common(39.65％);the herbs mainly targeted the Spleen,Lung,and Liver meridians,with the Spleen meridian being the primary target(20.45％).The most frequent co-occurrence was Spine Date Seed and Poria(223 times),and the optimal number of clusters was three,indicating high correlation among three groups of medicines.Conclusion In the treatment of insomnia,Professor Lu Guangrong adheres to the academic thought of disease first and syndrome secondly,and advocates the treatment principle of adjusting to individual conditions,making up the treatment principle of clarifying and mild,so as to restore the balance of Yin and Yang,the regulation of Ying and Wei,and the safety of five Zang organs.
基金项目
第七批全国老中医药专家学术经验继承项目(国中医药办人教函[2021]272号)
全国青年岐黄学者支持项目(国中医药人教发[2020]7号)
云南省中青年学术和技术带头人后备人才(202105AC160052)
云南省2020年高层次中医药人才学科带头人培养对象项目(云卫中医发展发[2021]1号)
NETL
NSTL
万方数据