摘要
过敏性紫癜也称为IgA血管炎,通常累及皮肤、胃肠道、关节和肾脏等部位的小血管.以非血小板减少性可触及的紫癜、关节炎或关节痛、弥漫性腹痛及肾损害:血尿和(或)蛋白尿为主要临床表现.约20％～80％的HSP患儿出现血尿和蛋白尿等肾脏损伤,且儿童过敏性紫癜复发率高,所以对于疾病的早期干预,改善其预后至关重要.现代医学对过敏性紫癜的发病机制仍不明确,各项评估病情及预后的指标较为肯定,而治疗方面目前尚无特异性的疗法,激素、免疫抑制、血液净化等治疗仅适用于重型过敏性紫癜.本病中医病因病机明确,主要与风、热、瘀、虚有关,病位在络,中医治疗过敏性紫癜临床疗效确切.
Abstract
Henoch-schönlein purpura(HSP),also known as IgA vasculitis,typically involves small blood vessels in the skin,gastrointestinal tract,joints,and kidneys.The main clinical manifestations include non-thrombocytopenic palpable purpura,arthritis or arthralgia,diffuse abdominal pain,and renal damage characterized by hematuria and/or proteinuria.Approximately 20％to 80％of children with HSP exhibit renal involvement such as hematuria and proteinuria,and the recurrence rate of allergic purpura in children is high.Therefore,early intervention in the disease and improving long-term prognosis is crucial.Western medicine still does not have a clear understanding of the etiology and pathogenesis of HSP,and there are affirmative indicators for predicting the course and prognosis of the disease.Currently,there is no specific therapy for HSP,and treatments such as corticosteroids,immunosuppressants,and blood purification are only applicable to severe cases of allergic purpura.Traditional Chinese medicine(TCM)has a clear understanding of the etiology and pathogenesis of HSP,which is mainly related to wind,heat,stasis,and deficiency,with the disease location being in the collaterals.The clinical efficacy of TCM in treating HSP is affirmative.
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