A Meta-analysis of Traditional Chinese Medicine Combined with Liraglutide in the Treatment of Type 2 Diabetes Mellitus Complicated with Obesity
Objective:To systematically evaluate the clinical effect of traditional Chinese medicine combined with Liraglutide in the treatment of type 2 diabetes mellitus complicated with obesity.Methods:The literature related to ran-domized controlled trials of traditional Chinese medicine combined with liraglutide in the treatment of type 2 diabetes mellitus with obesity were selected from CNKI,Wanfang,VIP,PubMed and other databases.The retrieval period was January 2023 and the data were analyzed by Revman5.4 software.Results:A total of 9 randomized controlled trials were included(n=699).Meta-analysis showed that when compared with the control group treated with liraglutide,the experimental group treated with traditional Chinese medicine combined with liraglutide had significantly lower fast-ing blood glucose[MD=-1.11,95％CI(-1.25,-0.97),P＜0.00001]and 2h postprandial blood glucose[MD=-1.23,95％CI(-1.41,).-1.05),P＜0.00001],HBA1c[MD=-0.92,95％CI(-1.42,-0.42),P=0.0003],body mass index[MD=-1.29,95％CI(-1.76,-0.82),P＜0.00001],insulin resistance index[SMD=-2.44,95％CI(-4.09,-0.79),P=0.004],and clinical response rate[OR=4.21,95％CI(2.14,8.29),P＜0.0001]were more significant.Conclusion:Traditional Chinese medicine combined with Liraglutide is su-perior to liraglutide alone in reducing blood glucose level,body mass index and improving clinical effective rate in type 2 diabetes mellitus patients with obesity.
Traditional Chinese MedicineLiraglutideType 2 DiabetesObesityClinical EffectMeta-Analysis
万方数据
维普
