Effect of Compound Danshen Dropping Pills Combined with Milrinone on Serum Biochemical Indexes and Heart Rate Variability in Patients with Chronic Heart Failure
Objective:To explore the effect of Compound Danshen Dropping Pills combined with Milrinone on se-rum biochemical indexes and heart rate variability in patients with chronic heart failure(CHF).Methods:A total of 80 CHF patients were selected and divided into 2 groups according to random number table method,control group(n=40)and observation group(n=40).On the basis of conventional treatment,the control group was given Milrinone treat-ment and the observation group was given Compound Danshen Dropping Pills combined with Milrinone treatment.The course of treatment was 8 weeks.The efficacy,cardiac function[left ventricular ejection fraction(LVEF),cardiac in-dex(CI),left ventricular end-diastolic diameter(LVEDD)],serum biochemical parameters[interleukin-8(IL-8),hypersensitive C-reactive protein(hs-CRP)]and heart rate variability[24h normal sinus RR interval standard deviation(SDNN),adjacent RR interval difference＞50 ms percentage of beats to total RR interval(PNN50),Low frequency band(LF)]of the two groups were compared.Results:Compared with that of the control group,the total effective rate of the observation group was higher(P＜0.05).After treatment,LVEF,CI,SDNN,PNN50 and LF in the two groups were increased(P＜0.05)while LVEDD,hs-CRP and IL-8 were decreased(P＜0.05),and the changes were more significant in the observation group(P＜0.05).Conclusion:Compound Danshen Dripping Pills combined with Milrinone has a definite effect in the treatment of CHF,can improve cardiac function,re-duce serum hs-CRP and IL-8 levels,and improve heart rate variability index.
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