摘要
目的 利用数据挖掘探寻《中国百年百名中医临床家丛书》中各位医家对于治疗眩晕病的用药规律.方法 通过《中国百年百名中医临床家丛书》获得数据来源,利用Excel、IBM SPSS Modeler 18.0、IBM SPSS Statistics 25.0、Origin 2022、Cytoscape 3.9.1等软件,对所获得数据进行频数、频率统计、关联规则分析、因子分析、系统聚类分析及复杂网络可视化分析等.结果 共纳入方剂191首,包含中药268种,使用总频数达2204次.使用频数≥20的中药共31种,累积频数1129次.使用频率较高的药物有茯苓、白术、天麻、陈皮、当归、白芍、菊花、石决明、川芎等:使用频率较高的药物功效以补虚药、平肝息风药、利水渗湿药等为主;药性以温为主;药味以甘、苦、辛为主;归经以入肝经、脾经为主;药物关联规则分析得到支持度较高的药对有"半夏-陈皮"、"茯苓-白术-半夏"、"半夏-天麻-茯苓"等;经系统聚类分析得出5大类,经因子分析提取到12个公因子.结论 眩晕基本病机与"风"、"痰"、"瘀"、"虚"有关,治法以利水渗湿、燥湿化痰、平肝熄风、补益脾肾、活血通络为主.
Abstract
Objective:To explore the prescription rules of famous doctors in the treatment of vertigo through the Series of One Hundred Chinese Medical Practitioners in the Past Century in China by using data mining.Methods:Da-ta source was obtained from Series of One Hundred Chinese Medical Practitioners in the Past Century in China,and the frequency,frequency statistics,association rule analysis,factor analysis,system cluster analysis and complex network visualization analysis were made on the obtained data by using Excel,IBM SPSS Modeler 18.0,IBM SPSS Statistics 25.0,Origin 2022 and Cytoscape 3.9.1.Results:A total of 191 prescriptions were included,including 268 kinds of herbs,and the total frequency of operation was 2204 times.There were 31 kinds of herbs with a frequency ≥20,and the cumulative frequency was 1129 times.The herbs with high frequency of operation were Poria,Atractylodis,Gastro-dia,Pericarpium,Angelica,Peoniae,Chrysanthemum,Concha Haliotidis,Ligusticum,etc.The efficacy of the herbs with high frequency were mainly to tonify deficiency,to suppress liver to calm wind,and clear damp to promote diure-sis.The properties of the herbs were mainly warm and the tastes were mainly sweet,bitter and pungent.The main channel tropism was mainly liver channel and spleen channel.The association rule analysis showed that the herb pairs with high support were Pinellia-Pericarpium,Poria-Atractylodis-Pinellia,Pinellia-Gastrodia-Poria and so on.Five categories were obtained by systematic cluster analysis,and 12 common factors were extracted by factor analysis.Conclusion:The basic pathogenesis of vertigo is related to wind,phlegm,stasis and deficiency.The main treatment is to clear damp to promote diuresis,eliminate dampness to dissolve phlegm,soothe liver to extinguish wind,tonify spleen and kidney and promote blood circulation to remove meridian obstruction.
基金项目
国家中医药局中医药古籍传承项目(国中医药科技函[2020]295号)
NETL
NSTL
万方数据