基于"窠囊"与"NF-κB信号通路"论治肺癌
Discussion on the Treatment of Lung Cancer Based on Cyst and NF-κB Signaling Pathway
李丹 1陈小芳 1李晓华 1邓兴华 1朱健环 1杨自成 1蔡政2
作者信息
- 1. 云南中医药大学,云南昆明 650500
- 2. 云南中医药大学第一附属医院/云南省中医医院,云南昆明 650021
- 折叠
摘要
肺癌属中医"肺积"的病理范畴,历代医家认为其病机是由"虚、痰、瘀、毒"所致,窠囊的主要物质基础是痰和瘀,本质是气血津液的失和,窠囊肺与肺积在形成方面具有相似性.通过研究发现"痰夹瘀"的窠囊之态等同于现代医学所说的肿瘤微环境,窠囊导致局部长期持续的炎症反应,损伤血管内皮,促进微血管新生,诱导基因突变,形成窠囊肺.而NF-κB作为一种典型的促癌、促炎的重要信号通路,进而认为窠囊的形成与激活NF-κB信号通路有关,因此强调扶正、破瘀、消痰、解毒以透窠囊作为肺癌的基本治法.
Abstract
Lung cancer belongs to the pathological category of"lung accumulation"in traditional Chinese medi-cine.Doctors of all dynasties think that its pathogenesis is caused by deficiency,phlegm,stasis and poison".The main material basis of the cyst is phlegm and stasis,and the essence is the disharmony of qi,blood and body fluid.By means of research,it is found that the state of"phlegm with blood stasis"is equivalent to the tumor microenvironment in modern medicine,which leads to long-term local inflammation,damages vascular endothelium,promotes microan-giogenesis,induces gene mutation and forms cystic lung.NF-κB is a typical pro-cancer and pro-inflammatory sig-naling pathway,and it is believed that the formation of the cyst is related to the activation of the NF-κB signaling pathway,so it is emphasized that the basic treatment of lung cancer is to strengthen the right,break blood stasis,elim-inate phlegm,detoxify and clear cyst.
关键词
窠囊/NF-κB信号通路/痰/瘀/肺癌Key words
Cyst/NF-κB Signaling Pathway/Phlegm/Stasis/Lung Cancer引用本文复制引用
基金项目
云南省科技厅-云南中医药大学联合专项(2019FF002-048)
云南省教育厅科学研究项目(2022Y338)
出版年
2024
NETL
NSTL
万方数据