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八正散中药复方治疗泌尿系感染Meta分析

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目的 利用Meta分析观察八正散中药复方治疗泌尿系感染的有效性和安全性.方法 检索万方数据库、中国生物医学文献数据库、the Cochrane Library、维普数据库、Pubmed数据库、CNKI(China national knowl-edge infrastructure)数据库,搜集八正散中药复方治疗泌尿系感染的随机对照治疗(randomized controlled trial,RCT),并进行方法学质量评价,采用RevMan5.4软件进行统计分析,进行亚组分析并发表偏倚评估.结果 有11篇RCT文献纳入本项研究,总共纳入研究的病例937例.Meta分析显示八正散中药复方治疗泌尿系感染治愈率(RR=1.51,95%CI 为 {1.32~1.72 },P<0.000 01)、显效率(RR=0.88,95%CI 为{0.68,1.13 },P=0.31)、有效率(RR=-0.08,95%CI 为{-0.12~-0.03 },P=0.002)、总有效率(RR=1.14,95%CI 为{1.09,1.18},P<0.000 01)、不良反应(RR=0.47,95%CI为{0.03,7.22},P=0.59)效果明显优于单纯使用抗生素组,差异具有统计学意义(P<0.05).结论 临床治疗泌尿系感染应用八正散中药复方疗效显著、历史悠久,在减少不良反应和提高患者生活质量以及控制疾病进展、减少复发率等方面,具有独特优势.
Meta-analysis of Bazheng Powder in the Treatment of Urinary Tract Infection
Objective:To observe the efficacy and safety of Bazheng Powder in the treatment of urinary tract in-fection by meta-analysis.Methods:Wanfang database,China Biomedical Literature Database,The Cochrane Librar-y,VIP database,Pubmed database and CNKI database were searched to collect randomized controlled trials(RCT)on the treatment of urinary tract infections with Bazheng Powder and the methodological quality was evaluated.Statistical analysis was performed using RevMan5.4 software,subgroup analysis was made,and bias assessment was published.Results:There were 11 RCT articles included in this study,including a total of 937 cases.Meta-analysis showed that the cure rate of Bazheng Powderin the treatment of urinary tract infection was as(RR=1.51,95%CI{ 1.32-1.72 },P<0.000 01),marked effective rate as(RR=0.88,95%CI{0.68,1.13 },P=0.31)and effective rate as(RR=-0.08,95%CI{-0.12~-0.03},P=0.002),total effective rate as(RR=1.14,95%CI{ 1.09,1.18},P<0.000 01),adverse reactions(RR=0.47,95%CI {0.03,7.22},P=0.59).The effect was significantly better than that of simple antibiotics group,and the difference was statistically significant(P<0.05).Conclusion:The clinical treatment of urinary tract infection with Bazheng Powder has a remarkable effect with a long history,and has its unique advantages in reducing adverse reactions,improving patients'quality of life,controlling disease progression and reduc-ing recurrence rate.

Bazheng PowderUrinary Tract InfectionMeta-analysisEffectivenessSafety

范春美、马斯棋、丁克凡、张春和、陈淑慧、赵梓钦、文鑫邦、杨毅坚

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云南中医药大学,云南昆明 650500

云南中医药大学第一附属医院,云南昆明 650021

八正散中药复方 泌尿系感染 Meta分析 有效性 安全性

国家自然科学基金地区科学基金项目

81860853

2024

云南中医中药杂志
云南省中医中药研究院,云南省中医药学会

云南中医中药杂志

影响因子:0.598
ISSN:1007-2349
年,卷(期):2024.45(7)
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