首页|育肾养卵方治疗肾虚型高龄卵巢储备功能减退的临床研究

育肾养卵方治疗肾虚型高龄卵巢储备功能减退的临床研究

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目的 观察育肾养卵方治疗肾虚型高龄卵巢储备功能减退的临床疗效.方法 将90例肾虚型高龄卵巢储备功能减退患者,按照随机数字表法分为治疗组和安慰剂组,每组45例.治疗组予口服育肾养卵方,安慰剂组予口服安慰剂,连续治疗3个月经周期.观察2组患者血清基础性激素(FSH、LH、E2、FSH/LH)、抗缪勒管激素(AMH)、窦卵泡计数(AFC)、中医证候积分、卵巢动脉血流的变化和安全性指标.结果 治疗后2组间比较,治疗组血清FSH、LH、FSH/LH水平明显低于安慰剂组(P＜0.05),血清E2、AMH水平高于安慰剂组(P＜0.05);治疗组窦卵泡数明显高于安慰剂组(P＜0.05);治疗组中医证候积分明显低于安慰剂组(P＜0.05);治疗组PI、RI明显低于安慰剂组(P＜0.05),PSV高于安慰剂组(P＜0.05).结论 育肾养卵方治疗肾虚型高龄卵巢储备功能减退,临床疗效显著,可以有效改善患者的临床症状,增加窦卵泡数量,其作用机制可能与调节基础性激素水平,改善卵巢动脉血供有关.
Clinical Study of Yushen Yangluan Prescription in the Treatment of Elderly Ovarian Reserve Dysfunction with Renal Deficiency Type
Objective:To observe the clinical effect of Yushen Yangluan Prescription in the treatment of elderly ovarian reserve dysfunction(ORD)with renal deficiency type.Methods:90 elderly ORD patients with renal deficiency type were divided into treatment group and placebo group according to random number table method,45 cases each group.The treatment group was given oral Yushen-Yangluan Prescription and the placebo group was given oral place-bo for 3 consecutive menstrual cycles.The changes of serum basic sex hormone(FSH,LH,E2,FSH/LH),anti-Muller hormone(AMH),sinus follicle count(AFC),TCM syndrome score,ovarian artery blood flow and safety inde-xes were observed in the two groups.Results:After treatment,the levels of serum FSH,LH and FSH/LH in the treat-ment group were significantly lower than those in the placebo group(P＜0.05),and the levels of serum E2 and AMH were higher than those in the placebo group(P＜0.05).The number of sinus follicles in the treatment group was sig-nificantly more than that in the placebo group(P＜0.05).The TCM syndrome score of the treatment group was signif-icantly lower than that of the placebo group(P＜0.05).PI and RI in the treatment group were significantly lower than those in the placebo group(P＜0.05),and PSV in the treatment group was higher than that in the placebo group(P＜0.05).Conclusion:Yushen Yangluan Prescription has significant clinical effect in the treatment of elderly ovarian reserve dysfunction(ORD)with renal deficiency type,which can effectively improve clinical symptoms and increase the number of sinus follicles.The mechanism of action may be related to regulating basic sex hormone levels and im-proving ovarian arterial blood supply.

Ovarian Reserve DysfunctionYishen Yangluan PrescriptionElderlyRenal Deficiency TypeClinical Research

谷灿灿、陈静、胡国华、万怡婷、王佳云、张亚楠、宁婧、HUANG Jia-mi

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上海中医药大学附属市中医医院,上海 200071

Shanghai Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China

卵巢储备功能减退 育肾养卵方 高龄 肾虚型 临床研究

上海市科学技术委员会课题上海市科学技术委员会课题上海市中医医院未来计划海派中医妇科流派诊疗中心建设上海市中医医院2022年度未来计划胡国华工作室

20Z2190040020Y21901400WUH2021ZYZLZX002WUH2022ZY-GZSA004

2024

云南中医中药杂志
云南省中医中药研究院,云南省中医药学会

云南中医中药杂志

影响因子：0.598
ISSN：1007-2349
年,卷(期)：2024.45(7)
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