Effects of Lenvatinib Combined with TACE on Tumor Markers and Immune Function in Patients with Liver Cancer
Objective To analyze the clinical effects of lenvatinib combined with transcatheter arterial chemoembolization(TACE)in the treatment of liver cancer and its effects on tumor markers and immune function related molecules.Methods 76 cases of liver cancer patients in Shangqiu Municipal Hospital from January 2021 to July 2023 were retrospectively studied and divided into control group and combination group with 38 cases each according to different treatment regiments.The control group was treated with TACE,and the combination group was treated with lenvatinib combined with TACE.Two months after treatment,the efficacy,adverse reactions,survival,tumor markers[alpha-fetoprotein(AFP),carbohydrate antigen 199(CA199),α-L-fucosidase(AFU),carcinoembryonic antigen(CEA)]and immune molecules[Toll-like receptor 2(TLR 2),TLR 4,myeloid differentiation factor 88(MyD 88)]were compared between the two groups.Results After 2 months of treatment,the disease control rate(DCR)of the combined group was 78.95%,which was higher than that of the control group 57.89%(P<0.05),and the objective response rate(ORR)of the combined group was 42.11%,which was not statistically significant compared with 26.32%of the control group(P>0.05).After 2 months of treatment,AFP,CA199,AFU and CEA in combination group were lower than those in control group(P<0.05),TLR2,TLR4 and MyD88 in combination group were lower than those in control group(P<0.05).There was no significant difference in the incidence of pain,fatigue,diarrhea,thrombocytopenia,hypertension,proteinuria and hand-foot syndrome between the two groups(P>0.05).The incidence of fever in combination group(15.79%)was lower than that in control group(36.84%)(P<0.05).The median overall survival(OS)and median progression-free survival(PFS)in combination group were higher than those in control group(P<0.05).Conclusion Lenvatinib combined with TACE is effective in the treatment of liver cancer,which can improve the level of immune dysfunction and tumor markers,increase ORR,OS and PFS,and the adverse reactions are controllable.
万方数据
维普
