Application of Remimazolam in Reducing Stress Response Induced by Tracheal Intubation in Thoracoscopic Thoracic Surgery
Objective To observe the effect of remimazolam on reducing the stress response induced by tracheal intubation in thoracic surgery.Methods This study was a prospective study that included 105 patients who underwent thoracic surgery.The enrolled patients were randomly divided into the conventional group(52 cases)and the experimental group(53 cases)using a computer-based randomization method.All patients received thoracoscopic thoracic surgery.The conventional group received routine general anesthesia during surgery,while the experimental group received remimazolam assisted general anesthesia.The anesthesia effects and safety of the two groups of patients were compared.Results Under different anesthesia schemes,the HR and MAP of the experimental group during tracheal intubation(T2)and 10 minutes after intubation(T3)were lower than those of the conventional group(P<0.05);the awakening time and PACU retention time of the experimental group were slightly higher than those of the conventional group,and the difference was not statistically significant(P>0.05);the RASS score of the experimental group was lower than that of the conventional group;the NE and Cor of the experimental group at T2 and T3 were lower than those of the conventional group(P<0.05).The incidence of anesthesia related adverse reactions in the experimental group was 13.21%(7/53),slightly higher than that in the conventional group of 9.62%(5/52)(P>0.05).Conclusion Remimazolam assisted general anesthesia can effectively maintain the stability of perioperative physical signs of patients undergoing thoracic surgery under thoracoscopy,which is of positive significance in improving the quality of recovery of patients and reducing the stress response caused by tracheal intubation.Moreover,this drug is safe and does not significantly increase the risk of anesthesia related adverse reactions.
万方数据
维普
