Study on the Effect of Pamidronate Disodium on Bone Metastasis Pain and Bone Fiber Structure in Lung Cancer Patients
Objective To observe the effect of pamidronate disodium on bone metastasis pain and bone fiber structure in lung cancer patients.Methods The study included 109 patients with lung cancer bone metastasis admitted to The Affiliated Hospital of Traditional Chinese Medicine of Nanyang Medical College from January 2021 to December 2022,all patients were accompanied with bone pain symptoms of different degrees.The patients were divided into the conventional group(54 cases)and the experimental group(55 cases)by random number table method.The conventional group was given comprehensive medical pain relief treatment,the experimental group was treated with pamidronate disodium in combination with the conventional group,and the improvement of bone fiber structure,changes in pain mediators,bone pain relief,and prognosis of the two groups of patients were compared.Results Before treatment,there was no statistical difference in bone fiber structure between the two groups(P>0.05);after treatment,the osteocalcin,C-terminal peptide of type Ⅰ collagen,procollagen type Ⅰ N-terminal propeptide of the experimental group were lower than the conventional group,with statistically significant differences(P<0.05).Before treatment,there was no statistical difference in pain media between the two groups(P>0.05);after treatment,the prostaglandin,serum lactate of the experimental group were lower the conventional group,and the difference was significant(P<0.05).Before treatment,There was no statistical difference in the degree of bone pain between the two groups(P>0.05);under different treatment regimens,the visual analogue scale after 1-3 cycle of treatment of the experimental group were lower than conventional group,and the difference was significant(P<0.05).Under different treatment regimens,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05);in the Functional Assessment of Cancer Therapy-lung cancer,the physical well-being,social/family well-being,emotional well-being,functional well-being of the experimental group were all higher than conventional group and the difference was significant(P<0.05).Conclusion Pamidronate disodium can effectively improve the bone fiber structure of lung cancer patients with bone metastasis,and alleviate bone pain symptoms by down-regulating the level of pain mediators.This drug has high safety and is also of positive significance for improving the long-term quality of life of patients.
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