Influence of Ursodeoxycholic Acid Combined with Ademetionine 1,4-butanedisulfonate on Liver Function and Pregnancy Outcomes in Puerperae with Intrahepatic Cholestasis of Pregnancy
Objective To explore the influence of ursodeoxycholic acid(UDCA)combined with ademetionine1,4-butanedisulfonate(SAMe)on liver function and pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy(ICP).Methods 82 ICP patients admitted to Shangrao Municipal Hospital from January 2020 to October 2022 were selected as the research subjects,divided into control group(n=41)and observation group(n=41)according to dynamic randomization method.All participants were given oral UDCA,and patients in the observation group were given intravenous drip of SAMe.Clinical symptoms[jaundice relief time,pruritus degree(Ribalta score)],bile metabolic function[total bile acid(TBA),bile acid(CBA),cholyglycine(CG)],liver function[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),γ-glutamyltranspeptidase(GGT)]in the two groups after 4 weeks of treatment were analyzed and compared,and the pregnancy outcomes(maternal-infant outcomes,neonatal Apgar score)after delivery were statistically analyzed in the two groups.Results After 4 weeks of treatment,pruritus and jaundice were relieved in both groups,and the required time in observation group were significantly shorter than those in control group(P<0.05).Serum levels of bile metabolic function indicators(TBA,CBA,CG)and liver function indicators(ALT,AST,GGT,TBIL)were decreased,and the above indicators were significantly lower in observation group than those in control group(P<0.05).During follow-up to delivery,compared with control group,the incidence rate of intrauterine distress in observation group was significantly lower(P<0.05)while the neonatal Apgar score was higher(P<0.05).There were no statistical differences in the incidence rates of other adverse outcomes during pregnancy between the two groups(P>0.05).Conclusion UDCA combined with SAMe in the treatment of ICP can accelerate the recovery time of pruritus and jaundice,promote the recovery of bile metabolism and liver function injury,improve the placental blood perfusion,maintain the ability of blood oxygen delivery,reduce the incidence rate of intrauterine distress,and improve the neonatal health status.
Intrahepatic cholestasis of pregnancyUrsodeoxycholic acidAdemetionine1,4-butanedisulfonateLiver function
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维普
