Effects of Adjuvant Therapy with Trimebutin Maleate on Gastrointestinal Dysfunction in Elderly Patients with Chronic Kidney Disease and Maintenance Hemodialysis
Objective To investigate the clinical value of trimebutin maleate adjuvant therapy in elderly patients with chronic kidney disease(CKD)and maintenance hemodialysis(MHD).Methods A total of 76 elderly patients with CKD-MHD in First People's Hospital of Xinxiang from March 2019 to March 2022 were randomly divided into control group and experimental group,with 38 cases in each group.Compare the gut microbiota,gastrointestinal function[gastrin(GAS),motilin(MOT),somatostatin(SS)],and renal function[serum creatinine(Scr),urea nitrogen(BUN)],β2-microglobulin(β2-MG),Cys-C,clinical indicators[hemoglobin(Hb),albumin(Alb),blood calcium(Ca),parathyroid hormone(PTH)],and inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]and occurrence of adverse reactions between two groups.Results After treatment,coliform bacteria and enterococcus in experimental group were lower than those in control group,bifidobacterium and lactobacillus were higher than those in control group(P<0.05);SS in the experimental group was lower than that in the control group,MOT and GAS were higher than that in the control group(P<0.05);the Scr,BUN,β-MG and Cys-C of the experimental group were lower than those of the control group(P<0.05);PTH,IL-6,TNF-α and CRP in the experimental group were lower than those in the control group,while ALB,Hb and blood Ca were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 13.16%compared to the control group of 5.26%,and the difference was not statistically significant(P>0.05).Conclusion Adjuvant treatment with trimebutine maleate can improve renal function,clinical indicators,and gut microbiota in elderly CKD-MHD patients,promote the recovery of gastrointestinal function,and reduce the expression of inflammatory factors,providing a reference for clinical treatment of gastrointestinal dysfunction in CKD.
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维普
