Exploring the Mechanism of Sargassum on Hyperplasia of Mammary Glands through Network Pharmacology
Objective To study the mechanism of sargassum in the treatment of hyperplasia of mammary glands(HMG)through network pharmacology.Methods The active constituents and targets of sargassum were searched and screened from TCMSP.The targets of HMG were obtained through database search.The PPI network was constructed for interaction analysis,and obtain core targets.Functional enrichment analysis was performed on the core targets.The network diagram of"component-target-pathway"of sargassum in treating HMG was constructed.Results The quercetin of sargassum and the core targets,such as HSP90AA1,MAPK1,TP53,EGFR and TNF were related to the treatment of HMG,which mainly involved in cellular response to chemical stress,membrane microdomain,membrane raft,mainly enriched in pathways in cancer,lipid and atherosclerosis.Conclusion This study has initially reveal the mechanism of treating HMG with sargassum through network pharmacology,which can provide reference for clinical application.
SargassumHyperplasia of mammary glandsNetwork pharmacologySignal pathwayMechanism
NETL
NSTL
万方数据
