Observation on the Clinical Effect of Zuogui Pills on Nucleoside(Acid)Antiviral Treatment of Bone Injury
Objective To observe the clinical effect of zuogui pills on nucleoside(acid)antiviral treatment of bone injury.Methods A total of 80 patients with bone injury caused by long-term antiviral treatment with nucleoside(acid)drugs in Jiujiang Traditional Chinese Medicine Hospital from March 2022 to March 2023 were divided into control group(n=40)and treatment group(n=40)using random number table method.The control group was given conventional treatment,and the treatment group was given zuogui pills orally.The course of treatment was 12 weeks.The clinical efficacy,liver and kidney function,bone mineral density and serum bone metabolism indexes were compared between the two groups.Results The effective rate of treatment group(87.50%)was higher than that of control group(67.50%)(P<0.05).Before treatment,the scores of TCM symptoms of the two groups were compared(P>0.05);after treatment,the scores of TCM symptoms of the treatment group were lower than those of the control group(P<0.05).Serum creatinine(Cr),urea nitrogen(BUN)and glomerular filtration rate(eGFR)of the two groups were compared before treatment(P>0.05);after treatment,Cr and BUN of the treatment group were lower than that of the control group,eGFR was higher than that of the control group(P<0.05).Before treatment,bone mineral density of femoral neck,Z score and T score were compared between the two groups(P>0.05);after treatment,bone mineral density of femoral neck in the treatment group was higher than that in the control group,and Z score and T score were lower than that in the control group(P<0.05).The serum calcium,serum phosphorus and alkaline phosphatase(ALP)of the two groups were compared before treatment(P>0.05),and the serum calcium and blood phosphorus of the two groups were compared after treatment(P>0.05).The ALP of the treatment group was higher than that of the control group(P<0.05).Conclusion Zuogui pills has significant clinical effect on nucleoside(acid)antiviral treatment of bone injury,which can improve patients'kidney function,increase bone mineral density and maintain normal serum bone metabolism indexes.
Nucleoside(acid)AntiviralBone injuryBone mineral density
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