Application and Retrospective Study of Triptorelin Acetate Combined with Low-dose Tibolone in 43 Cases of Patients with Ovarian Endometriosis after Surgery
Objective To investigate the effectiveness of triptorelin acetate in combination with low-dose tibolone in the treatment of ovarian endometriosis(EMS).Methods 86 patients with ovarian endometriosis admitted to The Affiliated Hospital of Xinyang Vocational and Technical College from January 2020 to December 2021 were selected as the research subjects.They were divided into different treatment groups,with 43 patients in each group.Two groups were treated with laparoscopic surgery,and the control group was treated with subcutaneous injection of triptorelin acetate,and the observation group was treated with oral tibolone on this basis.The clinical efficacy,bone density(bone density of the lumbar spine and femoral trochanter),sex hormone levels[luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E2)],indicators related to vascular endothelial function[vascular endothelial growth factor(VEGF),matrix metalloproteinase-2(MMP-2),MMP-9,multiligand proteoglycan-1(Syndecan-1)],and adverse effects were compared between the two groups.Results The total effective rate of the observation group was 95.35%higher than that of the control group 81.40%(P<0.05);the lumbar bone density at 6 months and 12 months after surgery was higher in the observation group than in the control group(P<0.05);there was no statistically significant difference in the bone density of the femoral trochanter between the 2 groups at 6 months and 12 months after surgery(P>0.05).Serum E2 and FSH levels were higher and LH levels were lower in the observation group than in the control group 6 months after surgery(P<0.05);serum VEGF,MMP-2,MMP-9,and Syndecan-1 levels were significantly lower in the combined group than in the control group 6 months after surgery(P<0.05);during the treatment period,the incidence of adverse reactions was 6.98%in the observation group compared with 11.63%in the control group,the difference was not statistically significant(P<0.05).Conclusion Triptorelin acetate combined with low-dose tibolone can effectively reduce postoperative bone density loss,regulate sex hormone levels and improve vascular endothelial function in EMS patients with definite,safe and reliable effects.
NETL
NSTL
万方数据
