Study on the Efficacy of Aspirin Combined with Labetalol in the Treatment of Gestational Hypertension
Objective To explore the efficacy of aspirin combined with labetalol in the treatment of gestational hypertension.Methods A study was conducted on 94 patients with gestational hypertension admitted to Yichun Maternal and Child Health Hospital from February 2022 to February 2023.Using the random number table method divided into two groups with 47 cases each.The control group was treated with labetalol hydrochloride tablets,while the observation group was supplemented with aspirin enteric coated tablets.Compare the changes in blood pressure test results,coagulation function index test results,placental hemodynamic index test results,quality of life comprehensive assessment questionnaire(GQOLI-74)scores,and differences in adverse pregnancy outcomes between the two groups of patients before and after treatment.Observe the differences in delivery weeks and delivery methods between the two groups.Results After treatment,the results showed that the detection results of diastolic blood pressure and systolic blood pressure in the observation group were lower than those in the control group(P<0.05);the detection results of thrombin time and prothrombin time in the observation group were higher than those in the control group,while the detection results of fibrinogen and D-dimer were lower than those in the control group(P<0.05);the resistance index and pulsatile index test results of the observation group were lower than those of the control group,while the time average flow velocity test results were higher than those of the control group(P<0.05);the physical function score,psychological function score,social function score,and material life state score of the observation group were higher than those of the control group(P<0.05).There was no significant difference in the incidence of adverse pregnancy outcomes between the two groups(P>0.05).The observation group had a later delivery week than the control group,and the vaginal delivery rate was higher than that of the control group(P<0.05).Conclusion The combination of aspirin and labetalol can effectively regulate blood pressure,improve coagulation function and placental ischemia and hypoxia status in patients with gestational hypertension,improve quality of life,and reduce adverse pregnancy outcomes,it is worthy of clinical application.
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