Comparison of the Effect and Safety of Different Doses of Mivacurium Chlorideon Anesthesia Induction in Children Undergoing Adenoidectomy
Objective To compare the effect and safety of different doses of mivacurium chlorideon in anesthesia induction of children adenoidectomy.Methods 110 cases of adenoidectomy in children admitted to Qinyang People's Hospital from January 2022 to June 2023 were selected and randomly divided into three groups.Adenoidectomy resection under general anesthesia was performed in all three groups,0.15 mg/kg mivacurium chlorideon was given to group A during anesthesia induction,0.20 mg/kg mivacurium chlorideon to group B,and 0.25 mg/kg mivacurium chlorideon to group C.The conditions and excellent rates of tracheal intubation in the three groups were compared,including the hemodynamic indexes[(including heart rate(HR),Mean arterial pressure(MAP),blood oxygen saturation(SpO2)]at admission(T0),immediately after intubation(T1),5 minutes after intubation(T2),extubation(T3),operation time,respiratory recovery time,recovery time,extubation time and adverse reaction rates.Results There was a statistically significant difference in tracheal intubation conditions among the three groups(P<0.05),and the excellent and good rates of group B and group C were 97.30%and 97.14%,respectively,which were higher than that of 78.95%in group A(P<0.05).The HR and MAP at T1 and T2 in group A were higher than those at T0(P<0.05),and those at T2 and T3 were lower than those at T1(P<0.05),which at T3 were lower than those at T2(P<0.05).HR and MAP in group B and group C at T1 were higher than those at T0(P<0.05),while those at T2 and T3 were lower than those at T1(P<0.05).The HR and MAP of group B and group C at T1 and T2 were lower than those of group A(P<0.05).The respiratory recovery time and recovery time of group A and group B were shorter than those of group C(P<0.05).The extubation time of group B was shorter than those of group A and group C(P<0.05).The incidence of adverse reactions in group C was higher than those in group A and group B(P<0.05).Conclusion In the anesthesia induction of pediatric adenoidectomy,compared with 0.15 mg/kg mivacurium chlorideon,0.20 mg/kg mivacurium chlorideon can improve the conditions of tracheal intubation,stabilize hemodynamic indexes.However,0.20 mg/kg mivacurium chlorideon can also shorten respiratory recovery,recovery time and the time of extubation,and reduce adverse reactions.
NETL
NSTL
万方数据
