Efficacy of Mycobacterium Phlei F.U.36 Injection Assisted with Cycloserine Regimen in the Treatment of Multidrug-resistant Pulmonary Tuberculosis and Its Effect on T Lymphocyte Subsets
Objective To explore the clinical efficacy of mycobacterium phlei F.U.36 injection assisted with cycloserine regimen in the treatment of multidrug-resistant pulmonary tuberculosis and its effect on T lymphocyte subsets.Methods According to the random envelope method,60 patients with multidrug-resistant pulmonary tuberculosis at Ruijin People's Hospital from June 2018 to June 2021 were divided into a control group(n=30,treated with cycloserine regimen)and an observation group(n=30,treated with cycloserine regimen and mycobacterium phlei F.U.36 injection).The clinical efficacy,inflammatory factors,T lymphocyte subsets and immune function were compared between the two groups,and the incidence of adverse reactions during treatment was counted.Results The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the observation group showed better improvement in inflammatory factors,lung function,T lymphocyte subsets and immune function compared to the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two treatment groups(P>0.05).Conclusion Mycobacterium phlei F.U.36 injection assisted with cycloserine regimen in the treatment of multidrug-resistant pulmonary tuberculosis can improve treatment efficacy,reduce the levels of IL-6,TNF-α and CRP,and improve lung function,T lymphocyte subsets and immune function without increasing adverse reactions.
NETL
NSTL
万方数据
