Isolation,Identification and Drug Sensitivity Analysis of Mycobacteria in Respiratory Tract Samples from 100 Patients with Suspected Pulmonary Tuberculosis
Objective To analyze the isolation,identification and drug sensitivity of mycobacteria in respiratory tract samples from 100 patients with suspected pulmonary tuberculosis.Methods The culture,isolation and drug sensitivity test of pathogens in respiratory tract samples were performed in the 100 patients with suspected pulmonary tuberculosis admitted to Xihu District Center for Disease Control and Prevention between January 2021 and October 2023.The identification results and drug resistance of mycobacteria were analyzed.Results In the 100 patients with suspected pulmonary tuberculosis,there were 24 confirmed cases.In the 96 strains of mycobacteria,there were 72 strains of non-tuberculosis mycobacteria and 24 strains of tuberculosis mycobacteria.The main non-tuberculous mycobacteria were mycobacterium intracellulare and mycobacterium abscessus[27 strains(28.13%),19 strains(19.79%)].Among In the 96 strains of mycobacteria,there were 49 strains from sputum samples and 47 strains from alveolar lavage fluid samples.In sputum samples,main mycobacteria were mycobacterium intracellulare and mycobacterium abscessus[15 strains(30.61%),10 strains(20.41%)].In alveolar lavage fluid samples,main mycobacteria were tuberculous mycobacteria and mycobacterium intracellulare[15 strains(31.91%),12 strains(25.53%)].The drug resistance rates of mycobacterium intracellulare were high to isoniazid,rifampicin and ofloxacin(70.37%,62.96%,59.26%),drug resistance rates of mycobacterium abscessus were high to capreomycin and ofloxacin(89.47%,84.21%),and drug resistance rate of tuberculous mycobacteria were high to streptomycin,rifampin and ethambutol(33.33%,29.17%,25.00%).Conclusion The proportion of non-tuberculosis mycobacteria in respiratory tract samples is relatively high in the 100 patients with suspected pulmonary tuberculosis,and the drug resistance was high to routine anti-tuberculosis drugs.In clinical treatment,rational medication should be taken based on the drug resistance of mycobacteria to ensure the effectiveness of drug treatment.
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