Analysis of Polymyxin B Blood Concentration and Adverse Reactions in ICU Patients
Objective To explore the blood concentration of polymyxins B and its adverse reactions in ICU patients in order to provide references for rational drug use in clinic.Methods This was a retrospective study.AUCss,24h influencing factors and nephrotoxicity were studied in 61 ICU patients who received polymyxins B treatment.Results The compliance rate of polymyxins B AUCss,24h was 37.70%(23/61).There were significant differences between creatinine clearance and Cmin and AUCss,24h(P<0.05),and there were negative correlations between creatinine clearance and Cmin(r=-0.45)and AUCss,24h(r=-0.34).Univariate and multivariate analysis showed that AUCss,24h were significantly correlated with infusion time(P<0.05),and the standard reaching rate of AUCss,24h in the infusion time>1 hour group was higher than that in the 1 hour group.Although AUCss,24h had no significant correlation with age and renal function(P>0.05),with increasing age or moderate and severe renal insufficiency,the rate of reaching the standard of AUCss,24h decreased.The incidence of polymyxins B related renal injury was 45.24%(19/42),and the proportion of AUCss,24h>100(mg·h)/L was higher in the renal injury group.Conclusion Polymyxins B AUCss,24h may be related to age,infusion time and renal function.Polymyxins B associated renal injury was associated with AUCss,24h>100(mg·h)/L.Monitoring of blood concentration and individualized administration should be carried out according to patients'conditions.
Polymyxins BTherapeutic drug monitoringBlood drug concentrationAdverse reaction
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