Clinical Efficacy of Different Types of Probiotics Combined with Gamma Globulin in the Treatment of Neonatal ABO Hemolytic Jaundice
Objective To explore the clinical efficacy of different types of probiotics combined with gamma globulin in the treatment of neonatal ABO hemolytic jaundice.Methods 160 children diagnosed with neonatal ABO hemolytic jaundice admitted to the Ganzhou People's Hospital from September 2022 to October 2023 were selected as the study subjects.Using a random number table method,the study subjects were randomly divided into four groups:blank,A,B,and C group,with 40 cases in each group.The four groups were all treated with gamma globulin infusion and blue light irradiation.Group A was added with bifidobacterium triple bacteria,group B was added with live bacillus subtilis and enterococcus faeciu,and group C was added with saccharomyces boulardii.Analyze and compare the clinical efficacy,serum bilirubin(TBIL)levels,weight gain,time to jaundice regression,average daily milk intake during treatment,and recurrence rate of jaundice regression between two groups.Results Before treatment,there was no significant difference in TBIL levels among the four groups(P>0.05);after treatment,the TBIL levels in all four groups decreased,with A,B,and C groups being lower than the blank group,with A group showing a greater decrease(P<0.05);the difference in TBIL levels between group B and group C was not significant(P>0.05).The weight gain of group A,B and C was higher than that of the blank group,and the jaundice regression time was shorter than that of the blank group.During the treatment period,the average daily milk intake was higher than that of the blank group(P<0.05),but the difference between groups A,B,and C was not significant(P>0.05);there was no significant difference in the incidence of jaundice recurrence among the four groups(P<0.05).Conclusion The combination of three probiotics and gamma globulin in the treatment of neonatal ABO hemolytic jaundice can effectively improve the symptoms of jaundice,reduce bilirubin levels,improve treatment effectiveness,and promote the growth and development of the child.However,the reduction of bilirubin levels by bifidobacterium triple bacteria is more significant.
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