Effects of Coenzyme Q10 Combined with Esmolol on Blood Lipid Levels and T Lymphocyte Subsets in Patients with Unstable Angina Pectoris of Coronary Heart Disease
Objective To observe the efficacy of coenzyme Q10 combined with esmolol in the treatment of unstable angina pectoris of coronary heart disease(CHD)and its effect on blood lipid level and T lymphocyte subsets.Methods A total of 116 patients with CHD unstable angina pectoris admitted to People's Hospital of Huiji District from January 2021 to January 2023 were selected as the study objects,and were divided into a single group(esmolol treatment)and a combined group(coenzyme Q10 combined esmolol treatment)according to the random even-odd allocation principle.The clinical efficacy,cardiac function[left ventricular end-diastolic diameter(LVDd),stroke output(SV),short-axis shortening rate(FS),ejection fraction(EF)],blood lipid level[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)],platelet activation[platelet surface cell differentiation antigen 40 ligand(CD40L),platelet-activated dependent granular surface membrane protein(CD62p),platelet-activated complex-1(PAC-1)],T lymphocyte subpopulation(CD3+,CD4+,CD4+/CD8+),microinflammatory status[pentamylin-3(PTX-3),lipoprotein-associated phosphatidylase A2(Lp-PLA2),Vascular Cell adhesion molecule-1(VCAM-1)]and adverse reactions were observed in the two groups.Results The curative effect of angina pectoris symptom and electrocardiogram in combined group was higher than that in single group(P<0.05).After treatment,LVDd,TC,TG,LDL-C,CD40L,CD62p and PAC-1 in combined group were lower than those in single group,while SV,FS,EF,CD3+,CD4+and CD4+/CD8+were higher than those in single group(P<0.05).The serum PTX-3,Lp-PLA2 and VCAM-1 levels in combined group were lower than those in single group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Coenzyme Q10 combined with esmolol is effective in the treatment of unstable angina pectoris of CHD.It can improve cardiac function,lipid metabolism,inhibit platelet activation,correct the disorder of T lymphocyte subset,relieve microinflammation,and has good safety.
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