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肺力咳合剂对肺炎患儿症状改善时间及免疫功能的影响

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目的 探讨肺力咳合剂对肺炎患儿症状改善时间及免疫功能的影响。方法 择取 2022 年 1 月至 2023 年 10 月于江西省妇幼保健院接受诊治的 94 例肺炎患儿,用随机数字表法分成两组,对照组、治疗组各 47 例。对照组予布地奈德混悬液治疗,在其基础上,治疗组予肺力咳合剂治疗,对比两组症状改善时间、炎症反应、免疫功能及肺功能。结果 治疗组咳嗽、肺啰音缓解时间与退热时间均较对照组短(P<0。05)。治疗后,两组C反应蛋白(CRP)、降钙素原(PCT)和肿瘤坏死因子α(TNF-α)均降低,且治疗组CRP、PCT、TNF-α较对照组低(P<0。05);两组免疫球蛋白(Ig)A、IgM与IgG均降低,且治疗组IgA、IgM与IgG较对照组低(P<0。05);两组用力肺活量(FVC)、最大呼气峰流速(PEF)、第 1 秒最大呼气量(FEV1)均增加,且治疗组PEF、FVC与FEV1 较对照组高(P<0。05)。结论 肺力咳合剂可减轻肺炎患儿炎症反应,调节免疫功能,改善肺功能,促症状缓解。
Effect of Feilike Mixture on Symptom Improvement Time and Immune Function of Children with Pneumonia
Objective To investigate the effect of feilike mixture on symptom improvement time and immune function of children with pneumonia.Methods 94 children with pneumonia treated in Jiangxi Maternal and Child Health Hospital from January 2022 to October 2023 were randomly divided into two groups with 47 cases in each control group and treatment group.The control group was treated with budesonide suspension,and the treatment group was treated with feilike mixture on the basis of the control group.Symptom improvement time,inflammatory response,immune function and lung function were compared between the two groups.Results The remission time of cough and pulmonary rales and fever in the treatment group were shorter than those in the control group(P<0.05).After treatment,C-reactive protein(CRP),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)were decreased in both groups,and CRP,PCT and TNF-α in treatment group were lower than those in control group(P<0.05);immunoglobulin(Ig)A,IgM and IgG were decreased in both groups,and IgA,IgM and IgG in the treatment group were lower than those in the control group(P<0.05);forced vital capacity(FVC),maximum peak expiratory flow rate(PEF)and 1second maximum expiratory volume(FEV1)were increased in both groups,and PEF,FVC and FEV1 in the treatment group were higher than those in the control group(P<0.05).Conclusion Feilike mixture can reduce inflammation,regulate immune function,improve lung function and promote symptom relief in children with pneumonia.

PneumoniaFeilike mixtureSymptoms improvedImmune function

饶志辉、张淑琴、许文霖

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江西省妇幼保健院,江西 南昌 330008

肺炎 肺力咳合剂 症状改善 免疫功能

2024

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江西省药学会

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影响因子:0.672
ISSN:1672-2809
年,卷(期):2024.21(3)