Effect of Chaihu-adds-longgu-muli Decoction Combined with Cetirizine Hydrochloride Tables on T Cell Subpopulation and Recurrence Rate in Patients with Chronic Urticaria
Objective To observe the effect of chaihu-adds-longgu-muli decoction combined with cetirizine hydrochloride tables on patients with chronic urticaria(CU).Methods A total of 78 CU patients(March 2022 to February 2023)were selected as study objects and randomly divided into control group and observation group with 39 cases each according to bicolor sphere method.The control group was given cetirizine hydrochloride tables,and the observation group was treated with chaihu-adds-longgu-muli decoction on the basis of control group.The clinical efficacy,clinical symptoms and signs,T cell subsets(CD4+,CD3+and CD4+/CD8+),inflammatory factor[interferon(IFN)-γ,interleukin(IL)-4,IL-10,transforming growth factor(TGF)-β1],adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of observation group was 97.44%higher than that of control group 79.49%,the difference was statistically significant(P<0.05).After treatment,the itching,the size and quantity of wind mass and the score of burning sensation of both groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the levels of TGF-β1,IL-10,CD8+and IL-4 in both groups decreased,and the levels of CD4+,IFN-γ,CD3+and CD4+/CD8+in observation group were lower than those in control group,and the levels of CD4+,IFN-γ,CD3+and CD4+/CD8+in observation group were higher than those in control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of observation group was 2.70%(1/37)lower than that of control group 18.42%(7/38),and the difference was statistically significant(P<0.05).Conclusion The combined treatment of chaihu-adds-longgu-muli decoction with cetirizine hydrochloride can improve the clinical signs,inhibit inflammatory factors,enhance immunity and reduce the recurrence rate of CU patients.
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