Analysis of the Therapeutic Effect of Insulin Degludec and Liraglutide Injection on Type 2 Diabetes Mellitus with Poor Glycemic Control
Objective To analyze the therapeutic effect of insulin degludec and liraglutide injection on type 2 diabetes mellitus with poor glycemic control.Methods Selected 24 patients with type 2 diabetes from Shenzhen People's Hospital,treated with insulin degludec and liraglutide injection.Observed the changes of these 24 patients in their body weight(WT),body mass index(BMI),fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2 hPG),glycated hemoglobin A1c(HbA1c),uric acid(UA),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),aspartate aminotransferase(AST),alanine aminotransferase(ALT),serum creatinine(SCR),glomerular filtration rate(eGFR),blood urea nitrogen(BUN)and Serum albumin(ALB)after 12 weeks of treatment as well as the side effects were observed.In addition,12 patients were reexamined for the above indicators after 4 weeks of treatment,and stratified data analysis was conducted.Results After 4 weeks of treatment with insulin degludec and liraglutide injection,the patients showed significant improvements in WT,BMI,FPG,2 hPG,HbA1c,TG,SCR,eGFR and BUN(P<0.05).The levels of UA,TC,LDL-C,HDL-C,AST,ALT and ALB were also improved but not statistically significant(P>0.05).After 12 weeks of treatment,the patients'WT,BMI,FPG,2 hPG,HbA1c,TC,ALT,eGFR,BUN and ALB were significantly improved compared with those before treatment(P<0.05),although the patients'UA,TG,LDL-C,HDL-C,AST,SCR were improved,the differences were not statistically significant(P>0.05).In addition,the reduction of HbA1c after treatment was(2.23±1.56)%,and the degree of reduction of HbA1c was correlated with baseline FPG(r=0.60,P=0.002)and 2 hPG(r=0.57,P=0.007).The decrease of WT after treatment was(3.12±3.95)kg,and the decrease of WT was not correlated with the baseline WT(r=0.367,P=0.078)and BMI(r=0.171,P=0.452).During the treatment,2 patients had hypoglycemia twice and the incidence of hypoglycemia was 8.33%.No serious hypoglycemic events occurred.Four patients had mild gastrointestinal reactions but were tolerable after approximately 1 week of treatment,and no patients withdrew from the study because of gastrointestinal reactions.Conclusion Insulin degludec and liraglutide injection has a good hypoglycemic effect on type 2 diabetic patients with poor glycemic control(HbA1c>7%).At the same time,it has a certain improvement in blood lipid,liver function,kidney function,and significant weight loss effect,and has good safety profile.
NETL
NSTL
万方数据
