Effect of Immunosuppressant Combined with Chinese Patent Medicine on Renal Function and Blood Lipid Level in Refractory Nephrotic Syndrome
Objective To investigate the effects of immunosuppressant combined with Chinese patent medicine on renal function and lipid levels in patients with refractory nephrotic syndrome(RNS).Methods Retrospective analysis in January 2019 to June 2023 treated 118 cases of patients with RNS from The First Affiliated Hospital of Gannan Medical University,according to the different treatment,divided into cyclophosphamide group(group A),cyclophosphamide+shenkang suppositories group(group B),cyclophosphamide+huangkui capsules group(group C),cyclosporine group(group D),cyclosporine+shenkang suppositories group(group E)and cyclosporine+huangkui capsules group(group F).According to the evaluation indexes of renal function,blood lipid level and adverse drug reactions,the changes of renal function and blood lipid level of cyclophosphamide or cyclosporine combined with Chinese patent medicine were analyzed.Results After treatment,24 h-UTP,ALB,CRE,UREA,TC,TG and LDL-C were significantly improved in all groups(P<0.05).24 h-UTP decreased significantly in group C compared with A group(P<0.05).The decrease of TC in group E was significantly higher than that in D group(P<0.05).Compared with D group,the decrease of 24 h-UTP and TC in group F were statistically significant(P<0.05).Conclusion Immunosuppressant cyclophosphamide and cyclosporine can effectively treat patients with RNS,and combined with huangkui capsules can reduce proteinuria excretion and high lipid level.Immunosuppressive agents combined with shenkang suppositories improve high lipid level.
NETL
NSTL
万方数据
