Objective Explore the digestive promoting effect of fructus aurantii extract on functional dyspepsia rats.Methods Rats were randomly divided into high,medium,and low-dose groups of total flavonoids,high,medium,and low-dose groups of alkaloids,positive control group,model control group,and blank control group.Except for the blank control group,all other groups were subjected to FD models.After 7 consecutive days of administration of the test substance,the gastric residual rate and small intestine propulsion rate were measured,and serum levels of motilin(MTL),gastrin(Gas),vasoactive intestinal peptide(VIP),serotonin(5-HT),and serotonin receptor 4(5-HTR4)were measured by separating serum samples.Results The small intestine propulsion rate of FD rats after administration of total flavonoids or high dose alkaloids was higher than that of the model control group(P＜0.05).The gastric residual rate of the total flavonoids group was lower than that of the model control group(P＜0.05).After administration of total flavonoids or high and medium doses alkaloids,the VIP content was significantly lower than that of the model control group(P＜0.05).The MTL content of the total flavonoids group was significantly higher than that of the model control group(P＜0.05).In addition,after administration high and medium doses of total flavonoids,the 5-HT content and 5-HTR4 content in FD rats were significantly higher than those in the model control group(P＜0.05).Conclusion Fructus aurantii alkaloids can inhibit VIP secretion in FD rats,thereby promoting small intestine peristalsis;the total flavonoids of fructus aurantii can improve gastric emptying and intestinal peristalsis in FD rats by promoting the secretion of MTL,inhibiting VIP secretion,and enhancing the secretion of 5-HT.It can also promote the secretion of 5-HT and strengthen its binding with 5-HTR4 receptors in the small intestine to enhance gastrointestinal motility in FD rats.
维普
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