The Clinical Efficacy and Hemorrhagic Transformation of Edaravone and Dexborneol Combined with Ginkgo Biloba Extract after Venous Hemolysis in Acute Cerebral Infarction
The Clinical Efficacy and Hemorrhagic Transformation of Edaravone and Dexborneol Combined with Ginkgo Biloba Extract after Venous Hemolysis in Acute Cerebral Infarction
Objective To investigate the effects of edaravone and dexborneol combined with ginkgo biloba extract on the clinical efficacy and hemorrhagic transformation(HT)of patients after venous hemolysis in acute cerebral infarction(ACI).Methods A total of 70 patients with ACI in Pingxiang People's Hospital from October 2021 to April 2023 were selected and divided into control group(35 cases)and observation group(35 cases)according to random number table method.All patients were treated with venous hemolysis,the control group was treated with ginkgo biloba extract;the observation group were treated with edaravone and dexborneol combined with ginkgo biloba extract.Clinical indicators before and after treatment were compared between the two groups for analysis,including neurological deficits and daily activity ability[National Institutes of Health Stroke Scale(NIHSS)and Barthel index scale],clinical efficacy,incidence of HT,and levels of neurofunction-related factors,and the incidence of complications in patients within six months after treatment.Results After treatment,NIHSS score in observation group was lower than that in control group,and ADL score was higher(P＜0.05);the total effective rate of the observation group was higher than that of the control group(P＜0.05);the incidence of HT in observation group was lower than that in control group(P＜0.05);the contents of S100β,NSE,VEGF and TNF-α in observation group were lower than those in control group(P＜0.05).Conclusion Edaravone and dexborneol combined with ginkgo biloba extract can improve the symptoms of neurological impairment in patients after venous hemolysis in ACI,improve clinical efficacy,reduce the incidence of HT,and reduce the levels of S100β,NSE,VEGF and TNF-α,thus improving the ability of daily living.
关键词
依达拉奉右莰醇/银杏叶提取物/急性脑梗死/静脉溶栓/临床疗效/出血性转化
Key words
Edaravone and dexborneol/Ginkgo biloba extract/Acute cerebral infarction/Venous thrombolysis/Clinical effect/Hemorrhagic transformation
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