Effectiveness Analysis of Children with Influenza Treated with Recombinant Human Interferon α2b Nebulised Inhalation Combined with Paramivir Injection
Objective To analyze the therapeutic effect of recombinant human interferon α2b nebulised inhalation combined with peramivir injection in children with influenza.Methods A retrospective analysis was performed on 88 children with influenza in Zhumadian Guangji Cardiovascular Hospital from August 2020 to August 2023,and they were divided into control group(receiving peramivir injection)and study group(receiving recombinant human interferon α2b nebulised inhalation combined with peramivir injection)according to different treatment plans,44 cases in each group.Compare the clinical efficacy,symptom improvement,length of stay and incidence of adverse reactions between the two groups,as well as serum inflammatory factors[tumor necrosis factor-α(TNF-α),monocyte chemoattractant protein-1(MCP-1),C-reactive protein(CRP),interleukin-6(IL-6)],immunoglobulin[immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)]before and after treatment.Results The total clinical effective rate of the study group 95.45％was higher than that of the control group 81.82％(P＜0.05).The improvement time of cough,sore throat,high fever and other symptoms in the study group was shorter than that in the control group(P＜0.05).Compared with the control group,TNF-α,CRP,IL-6 and MCP-1 were lower in the study group after treatment(P＜0.05).Compared with before treatment,IgA,IgM and IgG were increased in both groups,and more significantly in the study group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the study group(9.09％)and the control group(6.82％)(P＞0.05).Conclusion Recombinant human interferon α2b nebulised inhalation combined with peramivir injection can reduce inflammation,improve immune function and accelerate disease recovery in children with influenza,with significant effect and high safety.
InfluenzaRecombinant human interferon α2bPeramivir injectionInflammatory factorsImmunoglobulin
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维普
